Marie-Claude has been with IPST since 2012. She is the specialist in echocardiography and the laboratory technical team director. She likes new challenges and working within a team. In the future, she would like to increase her knowledge of other imaging devices in order to better serve our clients.
Cholestatic liver disease
Purpose
Cholestasis is a liver disease. It occurs when the flow of bile from your liver is reduced or blocked. Bile is fluid produced by your liver that aids in the digestion of food, especially fats. When bile flow is altered, it can lead to a buildup of bilirubin and development of liver inflammation and fibrosis development.
Method
Common bile duct is ligated under anesthesia. This ligation induces a complete cholestasis. After 3 weeks, mice develop a significant cholestasis with postal fibrosis.
Study outcome
Blood ALT, AST and total bilirubin. Liver collagen content and an extensive liver histology analysis.
Species
Mice
Marie-Claude Nault
Head of the Imaging Team
