“From running the experiments myself to designing them to be run by others, the initial steps have always been my favourite. Those moments when a sponsor explains the challenge he/she/they are facing, and together we brainstorm to assemble a solution. Eventually, a ground-breaking idea—a parameter, a test, something—comes to mind, which crystallizes the solution. At that point, we both know that this idea changes everything: it collapses obstacles and opens the path forward. That moment has remained one of my greatest motivators throughout the years.”
Dan’s undergrad studies in Biochemistry (Bishop’s University) were followed by graduate studies in Thoracic Physiology (Université de Sherbrooke). Dan’s post-graduate work was in Cardiovascular Pharmacology and Cardiology.
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Dual-pressure implanted telemetry animals
Purpose
Continuous recording of pressures or ECG signals while being treated with pharmaceutical agents. Dual pressure probes are often used in PAH models while ECG probes are used for QT-prolongation assessment of proarrhythmic agents.
Method
Telemetric probes are implanted to allowed conscious recording of various parameters to assess pharmaceutical agents.
Study Outcome
- PAP, SAP, ECG (PQRST intervals)
Compliance
Non-GLP
Species
Rats, guinea pigs, rabbits
Dany Salvail
Ph.D., Vice-President.
Analysis & guidance included. Always.
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At IPST we believe each study is worthy of tailored protocols designed to maximize the scientific and strategic value of the data generated. We believe in taking ownership of the studies entrusted to IPST while ensuring mutual collaboration for developing and agreeing to overall project plans.
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