Marie-Claude has been with IPST since 2012. She is the specialist in echocardiography and the laboratory technical team director. She likes new challenges and working within a team. In the future, she would like to increase her knowledge of other imaging devices in order to better serve our clients.
Heart failure model: CLP sepsis
Purpose
Heart failure results from complete septic shock symptoms.
Hypovolemia, exaggerated immune response, global ischemia.
Decreased cardiac output associated with ↘ ejection fraction, ↘ fractional shortening, ↘ everything
Severe, acute, essentially a survival model.
Method
Cecal ligation and perforation in adult rats leads to acute sepsis.
12 hours to induce treatment, model is generally over 72h post-CLP.
Study outcome
Cardiac echography (ultrasound)
Biomarkers (troponins, CKMB, BNP)
Histology
Species
Rats
Marie-Claude Nault
Head of the Imaging Team
