Monocrotaline-induced pulmonary hypertension

Purpose

To assess the effect of antihypertensive agents on pulmonary artery pressure and right ventricular hypertrophy

Method

Single injection of monocrotaline (MCT); a pyrrolizidine alkaloid which leads to endothelial dysfunction and damage associated with clinical pathogenesis of PAH in human. Severe PAH is observed after 28 days following the MCT injection.

Study Outcome

  • Hemodynamic parameters; mPAP, mSAP, RVSP, Pulse Pressure, PVR, Heart rate, saturation
  • Fulton’s index, Lung weight
  • Cardiac function parameters obtained by echocardiography; CO, SV, PAAT, Vmax, VTI, RV free wall thickness

Compliance

Non-GLP

 

Species

Rats

 

We help you design the study you need.

At IPST we rise to the challenge of designing out-of-the-box inventive studies with new endpoints, novel routes of administration and pioneering models.

At IPST we recognize the need to customize every preclinical assay in order to maximize its predictivity.

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Nam molestie dui sed imperd fermentum. Curabitur laoreet orci ut mi ullamcorper elementum. Etiam vel gravida enim, in vehicula arcu. Mauris laoreet sagittis eros, condimentum vehicula felis ornare ac.

Scientist Director

Charles-E. Laurent

Ph.D., Director of In-Vivo Pharmacology

“Over the past 13 years, I had the greatest opportunity to exploit my passion for science at IPST by contributing to the design, and validation of unique assays which are now routinely run and serve to quantify the efficacy in preclinical drug candidates. My greatest contribution was to see the increase in demand for efficacy services such as the rodent model of pulmonary arterial hypertension (PAH), as well as our intravascular thrombosis and hemostasis models.” Charles completed his doctorate in Pharmacology at the Université de Montreal followed by 4 years of post doctorate studies at the University of Pittsburgh in the Department of Molecular Genetics and Biochemistry. His field of expertise includes cardiovascular pharmacology and molecular biology.

Analysis & guidance included. Always.

Contact us to learn more about how IPST customizes each study design to maximize your strategic and scientific ROI.
Let’s talk

Let’s talk

At IPST we believe each study is worthy of tailored protocols designed to maximize the scientific and strategic value of the data generated. We believe in taking ownership of the studies entrusted to IPST while ensuring mutual collaboration for developing and agreeing to overall project plans.
Contact us