“Over the past 13 years, I had the greatest opportunity to exploit my passion for science at IPST by contributing to the design, and validation of unique assays which are now routinely run and serve to quantify the efficacy in preclinical drug candidates. My greatest contribution was to see the increase in demand for efficacy services such as the rodent model of pulmonary arterial hypertension (PAH), as well as our intravascular thrombosis and hemostasis models.” Charles completed his doctorate in Pharmacology at the Université de Montreal followed by 4 years of post doctorate studies at the University of Pittsburgh in the Department of Molecular Genetics and Biochemistry. His field of expertise includes cardiovascular pharmacology and molecular biology.
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Pressure overload induced by high-salt diet
Purpose
Heart failure results from volume overload.
Compensatory hypertrophy at 8 weeks with preserved EF.
Dilation starts after 8-10 weeks.
Method
Dahl salt-sensitive male rats
High salt diet (8%) ingested from age 7 weeks for up to 26 weeks
Unregulated Renin-Angiotensin System
Study outcome
Cardiac echography (ultrasound measured every 4 weeks)
Biomarkers (troponins, CKMB, ANP, NT-Pro-BNP)
Terminal invasive hemodynamics (BP, HR, ECG)
Histology
Species
Male rats
Charles-E. Laurent
Ph.D., Director of In-Vivo Pharmacology
