“Microscopic image analysis has been my great passion for over 25 years. The observation of the histopathological changes taking place in the new experimental animal models and the drawing of conclusions makes me really happy. I like the smell of the knowledge in the morning and the freedom of having science in my life.”
Marzena completed her Ph.D. in Factors Controlling Growth and Maturation of the Small Intestinal Structure and Function at The Kielanowski Institute of Animal Physiology and Nutrition. Postdoc studies on Hormonal Modulation of Pancreatic Secretion and Different Types of Pancreatitis at the Université de Sherbrooke. Her DVM was completed at the Warsaw University of Life Sciences.
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Type 1 Diabetes Mellitus (T1DM)
Purpose
Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by an absolute lack of insulin, resulting in a significant increase of the blood glucose level. Chronic hyperglycemia leads to a variety of complications such as neuropathy and nephropathy and increased risk of cardiovascular events.
Method
T1DM is induced by an intraperitoneal injection of Steptozotocin (STZ) or alloxan.
Study outcome
Blood glucose, insulin, C-peptide, and T1DM complication (kidney function)
Species
This model can be performed both in mice and rats
Marzena Biernat
Ph.D., Veterinarian and Histopathologist
