Emilie has headed a preclinical group within IPST for over a decade. She has directed dozens and dozens of GLP-compliant, and exploratory studies. Over the years, she has emerged as a specialist in innovation: new models, new methods, new modalities. As a natural hands-on scientist, she enjoys being provided with a technical request, and coordinating her team’s efforts to overcome the challenge and produce a ready-for-primetime preclinical model of respiratory or vascular efficacy.
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Volume overload induced by aorto-caval shunt
Purpose
Heart failure results from volume overload.
Some ventricular hypertrophy (starts at Wk 20).
Method
Create aortic-vena cava shunt using a needle
Study outcome
Cardiac echography (ultrasound measured every 4 weeks)
Biomarkers (troponins, CKMB, ANP, NT-Pro-BNP)
Terminal invasive hemodynamics (BP, HR, ECG)
Propanolol and atropine challenges
Histology
Species
Adult male Sprague Dawley rats
Emilie Dupré
Study Director
