Sugen-Hypoxia-induced pulmonary arterial hypertension

Purpose

To assess the effect of antihypertensive agents on pulmonary artery pressure and right ventricular hypertrophy

Method

Rat receives a single injection of Sugen 5416 and then housed in hypoxia (10% O2) for 21 days. Following the hypoxic period, animals are returned to ambient air for an additional 35 days.

Study Outcome

  • Hemodynamic parameters; mPAP, mSAP, RVSP, Pulse Pressure, PVR, Heart rate, saturation
  • Fulton’s index, Lung weight
  • Cardiac function parameters obtained by echocardiography; CO, SV, PAAT, Vmax, VTI, RV free wall thickness

Compliance

Non-GLP

 

Species

Rats

 

Dany Salvail

Ph.D., Vice-President.

“From running the experiments myself to designing them to be run by others, the initial steps have always been my favourite. Those moments when a sponsor explains the challenge he/she/they are facing, and together we brainstorm to assemble a solution. Eventually, a ground-breaking idea—a parameter, a test, something—comes to mind, which crystallizes the solution. At that point, we both know that this idea changes everything: it collapses obstacles and opens the path forward. That moment has remained one of my greatest motivators throughout the years.” Dan’s undergrad studies in Biochemistry (Bishop’s University) were followed by graduate studies in Thoracic Physiology (Université de Sherbrooke). Dan’s post-graduate work was in Cardiovascular Pharmacology and Cardiology.

Analysis & guidance included. Always.

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